Quantitative Structure-Activity Relationships of Fungicidal N-(3, 4-Diethoxyphenyl)carbamates

Fungicidal Activity of N-Phenylcarbamates (Part 6)

Abstract

For 30 N-(3, 4-diethoxyphenyl)carbamoyl esters with various alcoholic moiety substituents, their fungicidal activity against Botrytis cinerea resistant to benzimidazole fungicides was determined by the agar medium dilution method and the structure-activity relationships were analyzed by using the multiple regression technique. The hydrophobicity of the substituents was favorable to the activity. The activity was related parabolically to the maximum width of the substituents and the “β-branching” of the substituents was detrimental to the activity. The preventive activity of compounds against gray mold of cucumber caused by the resistant B. cinerea was determined by the foliar application in pot tests. The preventive activity was dependent on the magnitude of the fungicidal activity and the α-branching of the substituents on analysis by the adaptive least-squares method.