The Journal of Physical Fitness and Sports Medicine
Online ISSN : 2186-8123
Print ISSN : 2186-8131
ISSN-L : 2186-8131
Review Article
Influence of obesity on skeletal muscle contractile dysfunction in aging
Hiroaki Eshima
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ジャーナル フリー

2020 年 9 巻 5 号 p. 199-204

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Obesity and aging reduce skeletal muscle contractile function, which represents a reduction in muscle quality. Dysfunction of muscle contraction may contribute to a greater risk for diabetes, cardiovascular diseases, and cancer; therefore, the synergistic effects of obesity and aging on muscle function may exacerbate morbidity and mortality. However, evidence directly examining the synergistic effects of obesity and aging on muscle contractile function is lacking and controversial. We recently demonstrated that diet-induced obesity significantly exacerbates contractile dysfunction in aged skeletal muscle. The focus of this review is the effects of obesity on muscle contractile dysfunction in skeletal muscle, particularly during aging.

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© 2020 The Japanese Society of Physical Fitness and Sports Medicine

This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.
https://creativecommons.org/licenses/by-nc-nd/4.0/
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