Oseltamivir Enhances Hippocampal Network Synchronization

Atsushi Usami; Takuya Sasaki; Nobuhiro Satoh; Takahiro Akiba; Satoshi Yokoshima; Tohru Fukuyama; Kenzo Yamatsugu; Motomu Kanai; Masakatsu Shibasaki; Norio Matsuki; Yuji Ikegaya

doi:10.1254/jphs.SC0070467

Short Communications

Oseltamivir Enhances Hippocampal Network Synchronization

Atsushi Usami, Takuya Sasaki, Nobuhiro Satoh, Takahiro Akiba, Satoshi Yokoshima, Tohru Fukuyama, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Norio Matsuki, Yuji Ikegaya

著者情報

Atsushi Usami
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Takuya Sasaki
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Nobuhiro Satoh
Laboratory of Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Takahiro Akiba
Laboratory of Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Satoshi Yokoshima
Laboratory of Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Tohru Fukuyama
Laboratory of Synthetic Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Kenzo Yamatsugu
Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Motomu Kanai
Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Masakatsu Shibasaki
Laboratory of Synthetic Organic Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Norio Matsuki
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Yuji Ikegaya
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Japan

キーワード: oseltamivir, functional multineuron calcium imaging, network excitability

ジャーナルフリー
電子付録

2008 年 106 巻 4 号 p. 659-662

DOI https://doi.org/10.1254/jphs.SC0070467

View "Advance Publication" version (April 9, 2008).

詳細

抄録

Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation.

責任著者(Corresponding author)

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