Parishin C Attenuates Phencyclidine-Induced Schizophrenia-Like Psychosis in Mice: Involvements of 5-HT_1A Receptor

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Parishin C, a major component of Gastrodia elata BLUME (GE), was purified from GE. Because GE modulates the serotonergic system and the 5-HT_1A receptor is an important therapeutic target of schizophrenia, we examined whether parishin C affects phencyclidine-induced abnormal behaviors in mice. Phencyclidine-induced abnormal behaviors were significantly ameliorated by parishin C. These effects were reversed by WAY 100635, a 5HT_1A–receptor antagonist. Consistently, parishin C showed high affinity at 5-HT_1A receptor as well as a 5-HT_1A–agonist activity in a 8-OH-DPAT–stimulated [³⁵S]GTP-γS binding assay. Our results suggest that the antipsychotic effects of parishin C require activation of 5-HT_1A receptors.