Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms

Promsuk Jutabha; Naohiko Anzai; Toru Kimura; Atsuo Taniguchi; Wako Urano; Hisashi Yamanaka; Hitoshi Endou; Hiroyuki Sakurai

doi:10.1254/jphs.10228SC

Short Communications

Functional Analysis of Human Sodium-Phosphate Transporter 4 (NPT4/SLC17A3) Polymorphisms

Promsuk Jutabha, Naohiko Anzai, Toru Kimura, Atsuo Taniguchi, Wako Urano, Hisashi Yamanaka, Hitoshi Endou, Hiroyuki Sakurai

著者情報

キーワード: single nucleotide polymorphism, diuretic, urate

ジャーナルフリー

2011 年 115 巻 2 号 p. 249-253

DOI https://doi.org/10.1254/jphs.10228SC

View "Advance Publication" version (January 26, 2011).

詳細

抄録

We analyzed the functional properties of five nonsynonymous single nucleotide polymorphisms (SNPs) in the sodium-phosphate transporter NPT4 gene (SLC17A3) using the Xenopus oocyte expression system. NPT4 variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of [¹⁴C]para-aminohippurate, [³H]bumetanide, [³H]estrone sulfate, and [¹⁴C]urate, when each variant clone was expressed in the plasma membrane of oocytes. This study suggests the possibility that the genetic variation of NPT4 contributes to inter-individual differences in disposition of anionic drugs such as diuretics as well as certain endogenous organic anions such as urate.

責任著者(Corresponding author)

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