Involvement of Substance P and the Neurokinin-1 Receptor  in Radiation-Induced Hair Loss in Mice

Kouichi Yamamoto; Naoko Kureyama; Keiko Asano; Toshiji Ikeda; Atsushi Yamatodani

doi:10.1254/jphs.09256SC

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Involvement of Substance P and the Neurokinin-1 Receptor in Radiation-Induced Hair Loss in Mice

Kouichi Yamamoto, Naoko Kureyama, Keiko Asano, Toshiji Ikeda, Atsushi Yamatodani

著者情報

キーワード: radiation-induced hair loss, substance P, neurokinin-1 receptor

ジャーナルフリー早期公開

論文ID: 09256SC

DOI https://doi.org/10.1254/jphs.09256SC

この記事には本公開記事があります。

The final version of this article is now available: Vol. 112 (2010) , No. 1 p.118

詳細

抄録

We investigated the involvement of substance P (SP) and the neurokinin-1 receptor (NK₁R) in the development of radiation-induced hair loss in mice. A dose of 40 Gy of gamma irradiation induced hair loss from the 10th to at least the 60th day after irradiation. A specific NK₁R antagonist, CP-99,994, significantly delayed radiation-induced hair loss and reduced its severity. Furthermore, gamma irradiation induced the expression of preprotachykinin-A, a precursor protein of SP, mRNA in irradiated murine skin on the 10th and 30th days after irradiation. These results indicated that gamma irradiation-induced hair loss was mediated by SP via NK₁R.

責任著者(Corresponding author)

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