Effects of SA13353, a Transient Receptor Potential Vanilloid 1 Agonist, on Leukocyte Infiltration in Lipopolysaccharide-Induced Acute Lung Injury and Ovalbumin-Induced Allergic Airway Inflammation

Fumio Tsuji; Masaaki Murai; Kenji Oki; Hiroyuki Inoue; Minoru Sasano; Hiroyuki Tanaka; Naoki Inagaki; Hiroyuki Aono

doi:10.1254/jphs.09295SC

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Effects of SA13353, a Transient Receptor Potential Vanilloid 1 Agonist, on Leukocyte Infiltration in Lipopolysaccharide-Induced Acute Lung Injury and Ovalbumin-Induced Allergic Airway Inflammation

Fumio Tsuji, Masaaki Murai, Kenji Oki, Hiroyuki Inoue, Minoru Sasano, Hiroyuki Tanaka, Naoki Inagaki, Hiroyuki Aono

著者情報

キーワード: SA13353, transient receptor potential vanilloid 1, lung inflammation

ジャーナルフリー早期公開

論文ID: 09295SC

DOI https://doi.org/10.1254/jphs.09295SC

この記事には本公開記事があります。

The final version of this article is now available: Vol. 112 (2010) , No. 4 p.487

詳細

抄録

We recently demonstrated that SA13353, a transient receptor potential vanilloid 1 (TRPV1) agonist, reduced the severity of the symptoms of kidney injury, arthritis, and encephalomyelitis in disease models. Here, we investigated the effects of orally administered SA13353 on leukocyte infiltration in lipopolysaccharide (LPS)-induced acute lung injury and ovalbumin-induced allergic airway inflammation. In LPS-induced lung injury, SA13353 attenuated neutrophil infiltration and the increase of TNF-α and CINC-1 levels. In allergic airway inflammation, SA13353 tended to inhibit leukocyte infiltration and attenuated the increase of IL-4 and IL-12p40. These results suggest that somatosensory TRPV1 may play an anti-inflammatory role in lung inflammation.

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