Roles of β- and α2-Adrenoceptors Within the Central Nucleus of the Amygdala in the Visceral Pain–Induced Aversion in Rats

Satoshi Deyama; Azusa Takishita; Sachi Tanimoto; Soichiro Ide; Takayuki Nakagawa; Masamichi Satoh; Masabumi Minami

doi:10.1254/jphs.10139SC

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Roles of β- and α₂-Adrenoceptors Within the Central Nucleus of the Amygdala in the Visceral Pain–Induced Aversion in Rats

Satoshi Deyama, Azusa Takishita, Sachi Tanimoto, Soichiro Ide, Takayuki Nakagawa, Masamichi Satoh, Masabumi Minami

著者情報

キーワード: amygdala, emotion, visceral pain

ジャーナルフリー早期公開

論文ID: 10139SC

DOI https://doi.org/10.1254/jphs.10139SC

この記事には本公開記事があります。

The final version of this article is now available: Vol. 114 (2010) , No. 1 p.123

詳細

抄録

We investigated the roles of β- and α₂-adrenoceptors within the central nucleus of the amygdala (CeA) in the negative affective and sensory components of visceral pain in rats. We observed a dose-dependent reduction of intraperitoneal acetic acid-induced conditioned place aversion by bilateral injections of timolol, a β-adrenoceptor antagonist, or clonidine, an α₂-adrenoceptor agonist, without reducing writhing behaviors. These data suggest a pivotal role of intra-CeA adrenoceptors in the negative affective, but not sensory, component of visceral pain.

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