Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613

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Pramipexole Upregulates Dopamine Receptor D2 and D3 Expression in Rat Striatum
Naohito TokunagaMohammed Emamussalehin ChoudhuryNoriko NishikawaMasahiro NagaiTomoaki TujiiHirotaka IwakiMika KanetaMasahiro Nomoto
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ジャーナル フリー 早期公開

論文ID: 12096SC

この記事には本公開記事があります。
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Randomized clinical trials have shown that pramipexole has an antidepressant effect in patients with Parkinson’s disease. We investigated the comparative efficacy of pramipexole toward dopamine receptor D2 and D3 expression in rat brain. Groups of rats were treated subacutely with pramipexole (1 mg/kg), imipramine (10 mg/kg), or bromocriptine (5 mg/kg), with appropriate controls. Using real-time RT-PCR and immunoblotting, dopamine receptor D2 and D3 expression was up-regulated in the striatum following pramipexole treatment, while imipramine and bromocriptine had no significant effects. These findings support that pramipexole exerts additional therapeutic benefits such as decreasing depression by increasing dopamine receptor D3 expression in the striatum.
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© 2012 The Japanese Pharmacological Society
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