HYPERSENSITIVE TOXICITY OF 5-n-BUTYL-1-CYCLOHEXYL-2, 4, 6-TRIOXOPERHYDROPYRIMIDINE IN THE PREGNANT RAT

抄録

5-n-Butyl-l-cyclohexyl-2, 4, 6-trioxoperhydropyrimidine (BCP), a new antipyretic antiphlogistic agent, has been reported to differ from aminopyrine and phenylbutazone in lack of central convulsion in mice and rats as well as in mildness of the convulsion caused by the toxic doses in rabbits and dogs (1). Respiratory depression was the usual cause of death following excessive doses of BCP. The oral subchronic toxicity of BCP, aminopyrine and phenylbutazone in rats was reported by Okamoto (2) and Araki (3). According to their results, BCP in the daily doses above 800 mg/kg produced slight degeneration and destruction of the convoluted tubular epithels in the kidney, while phenylbutazone in the lesser doses resulted not only in the similar changes in the kidney, but also in obvious degeneration of the liver cells and the cardiac muscle fibers. The necessary prerequisite of a clinically available drug should be superiority of the main pharmacological effects and also minority of the side effects. During the toxicological studies of the anti phlogistics, the present author found that the lethal dose of BCP in the pregnant rats was markedly different from that in the non-pregnant ones. Therefore, attemt has been made in the present report whether the lethal response to the compound is conditioned by sex or gestation.