Abstract
The metabolic degradation of PGE, was studied by the incubation of 3H-PGE1 with rat and dog plasma and thoracic lymph and the homogenates of various rat and dog tissues. It was observed that rat and dog plasma metabolize very little PGE1 even when incubated for one hr. Very little metabolic degradation of PGE1 was found by dog thoracic lymph. In contrast, rat and dog lung and kidney metabolize PGE1 very rapidly, and approx. 95% of PGE1 was converted to a less polar metabolite within 20 min of incubation. The metabolic degradation of PGE, was also rapid in the homogenates of rat stomach and jejunum, but the velocity of this reaction in these homogenates was slower than that in the rat or dog lung and kidney homogenates.
