EFFECT OF ADRENERGIC BLOCKING AGENTS ON SYMPATHOMIMETIC AMINES INDUCED HYPERGLYCEMIA AND HYPERLACTACIDEMIA

Abstract

Sympathomimetic amines epinephrine and isoproterenot were administered to dogs, rabbits and pigeons, and effects on blood glucose and blood lactic acid levels were studied. Alpha and beta adrenergic receptor blocking drugs were employed to block the metabolic effects of the amines to elucidate the exact receptor status regarding the metabolic actions of sympathomimetic amines on carbohydrate metabolism. The results suggest that the receptors associated with hyperglycemic response vary depending on the species. In dogs, receptors are of beta type while in rabbits and pigeons both alpha and beta type of receptors appear to play a role. The hyperlactacidemic response, however, is associated with beta receptors in all animals studied herein.