抄録
In isolated splenic capsules of mouse, rat, guinea pig, rabbit, cat and dog, either a single or a cumulative dose of l-and dl-isoproterenol at a concentration higher than 10-9 M, induced a relaxation which was inhibited or blocked with pretreatment of 10-5 M propranolol. At a concentration of 5 × 10-6 M to 10-5 M l- and dl-isoproterenol, an inverse contraction was induced, and such response was prevented or reversed to one of relaxation in the presence of 10-5 M phentolamine. Application of 10-5 M epinephrine produced a strong contraction and such was reversed to one of relaxation after addition of 10-4 M phentolamine. This relaxation was reduced or blocked with pretreatment of 10-5 M propranolol. Thus, it was confirmed that both α- and β-receptors exist in the splenic capsule area of these different species.
