Abstract
In a previous paper [Kobayashi, Ohashi and Takeuchi (1)] we reported that when calcium or sodium salt of mesoxalic acid was administered to dogs and rabbits made diabetic with alloxan, the sugar content of their urine either was reduced or dropped to zero and their blood sugar level fell. Further, if the animals were more severely afflicted, ketone bodies in the blood and the NPN of the urine also decreased. It was reported that none of these effects of mesoxalate was visible in depancreatized dogs. It seems obvious, therefore, that the activity of mesoxalates on alloxan diabetic animals is closely related to the function of the pancreas. Herein is reported a series of experiments conducted to clarify the mechanism of action of the compounds.
