The Japanese Journal of Pharmacology
Online ISSN : 1347-3506
Print ISSN : 0021-5198
ISSN-L : 0021-5198
Protective Effect of a High Protein Diet against the Toxicity of Some Organophosphorus Compounds in Albino Rats
Ajit K. ChatterjeeUsha Kaveeshwar
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ジャーナル フリー

1991 年 57 巻 2 号 p. 147-152

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抄録
The present investigation deals with determining the efficacy of a high protein diet (HPD) in combating toxicity in albino rats of some organophosphorus compounds (OPCs) that follow dissimilar metabolic patterns in a living system. As assessed by an increase or decrease in the levels of some biochemical and nutritional parameters, the high protein diet containing 59% protein seems to have a beneficial effect in alleviating toxicity of low but prolonged doses of OPCs over the standard diet (SD) containing 19% protein. OPCs undergoing direct detoxication in a living system like diisopropyl phosphoro-fluoridate (DFP) appear to be more susceptible to HPD than those undergoing biotoxication like EPN (O-ethyl O-p-nitrophenyl phenyl-phosphonothioate) and malathion (S-(1, 2-dicarbethoxyethyl) O, O-dimethyldithio-phosphate).
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© The Japanese PharmacologicalSociety
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