抄録
A clinicopathological study was carried out using 55 autopsy cases of collagen disease. Incidence of vascular involvement of the kidney was the highest in polyarteritis nodosa (PN), and higher in Wegener's granulomatosis (WG), mucocutaneous lymph node syndrome (MCLS), allergic granulomatous angiitis (AGA), rheumatoid arthritis (RA) progressive systemic sclerosis (PSS), and systemic lupus erythematodes (SLE), than in dermatomyositis (DM). SLE showed more distinctive and more variegated glomerular lesions, while RA showed equal involvement of small arteries and glomeruli. Veins were damaged by angiitis in RA. Five cases of multiple glomerular microthromboses were noticed, and those were often related to rapidly progressive renal failure. From our previous observations on the fibrinolytic and fibrinolytic inhibitory activities of the kidney (Tanaka K: In. Soc. Path. Jap.1977, 66: 3-26), it is suggested that the kidney is easily affected by the formation of thrombi due to low fibrinolytic and high fibrinolytic inhibitory activities in the cortex, and that such glomerular microthromboses deteriorate renal lesions due to angiitis. When renal functions rapidly deteriorate in patients with systemic vasculitis, a possibility of disseminated intravascular coagulation syndrome (DIC) should be considered.
