抄録
The distribution of fibronectin in human renal glomeruli with a variety of pathologic disorders was studied on biopsy specimens by immunofluorescence method. The distribttion pattern was classified into two groups. One was the mesangial patternn in which fibsonectin fluorescence was restricted mainly to the mesangial area. Another was the capillary pattern in which the presence of the fluorescence along the capillary walls in an continus manner was found in addition to the presence in the mesangial area. The mesangial pattern was found in normal kidneys and in the majority of the cases without thickening of capillary walls or without deposits in the basement membrane. The capillary pattern was observed in the most of the cases associated with thickening of capillary walls or the deposits. Fibrin deposition was found in the group of the capillary pattern in a significantly higher frequency then that in the group of the mesangial pattern. Furthermore, fibrin deposition in the capillary pattern was seen mainly along the capillary walls. In these cases with fibrin deposition, the deposits of α2-plasmin inhibitor and plasminogen, which are major components of the fibrinolytic system, were also seen along the capillary walls in high frequencies. There was a significant association of the capillary pattern with nephrotic syndrome. However, the frequency of the capillary pattern in the cases with nephrotic syndrome was not significantly high, suggesting the presence of additional factors causing the capillary pattern other than nephrotic syudrome.
