腎動脈阻血後の腎内血流分布と腎組織内カテコールアミンの変動

抄録

It is known that renal blood flow is reduced after clamping of the renal artery. But there are few studies of renal blood distribution after ischemia and its mechanisms are still poorly understood. Changes of renal blood distribution were studied in dogs using a four channel hydrogen gas electrode before and after one hour ischemiao In the same experiment alternation of catecholamine content (noradrenaline, adenaline and dopamine) in the renal tissue were examined electrochemically with a high-pressure liquid chromatographic technique. In each expriment the renal tissue was divided into four areas: cortex, juxtamedullary cortex, outer medulla and inner medulla.1) Before ischemia, blood flow was high in the cortex, juxtamedullary cortex and outer medulla as compared with the inner medulla.2) After ischemia, blood flow was decreased significantly in the cortex and juxtamedullary cortex, but only moderately in the outer medulla and inner medulla3) Before ischemia, the noradrenaline concentration was high in the cortex, juxtamedullary cortex and outer medullae But the inner medulla contained very little noradrenaline. The adrenaline and dopamine concentrations were low as compared with the noradrenaline except in the inner medulla.4) After ischemia, the noradrenaline concentration was elevated significantly in the cortex, juxtamedullary cortex and outer medulla. The adrenaline and dopamine concentrations were not altered in any regions.5) It is concluded that noradrenaline may have an effect on the intrarenal hemodynamic changes after ischemia as a causative factor.