ヒト成長ホルモン剤(SM-9500,ジェノトロピン®)の小児腎移植患者の成長障害に対する臨床評価
1995 年 37 巻 3 号 p. 194-200
詳細
1995 年 37 巻 3 号 p. 194-200
We treated 27 children with renal transplantation who showed growth failure due to deteriolated graft function and/or corticosteroids therapy with recombinant growth hormone (r-hGH) to improve their growth disturbance. The dose of rhGH was either 0.5 or 1.0 IU/kg/week. After 12 months treatment of r-hGH, growth velocity was significantly increased in both groups. Growth velocity was improved from 5.0±2.9cm/year to 7.7±2.3cm/year, P<0.05, in0.5IU group and 3.7±2.4cm/year to 6.3±3.3cm/year, P<0.05, in1.0 IUgroup. The most important side effect of r-hGH was relevant to graft function. 7 out of all 27 children showed deteriolation of graft function. However only 2 children showed significant decreases in their graft functin during r-hGH therapy. Thus we conclude that r-hGH therapy was effective to improve growth failure in uremic children even after renal transplantation due to poor graft function and/or corticosteroids therapy.
