実験的尿路感染症 (予報)

とくに線維素溶解酵素系との関係について

抄録

In the development of non-specific urinary tract infections, the endogenous conditions existing mainly in the host are to be taken into consideration with the same importance to the activity of bacteria.
As one of the endogenous conditions, the experimental urinary tract infection was produced by injecting intravenously E. Coli into the rabbits given auto-sensitization like treatment in a wide sense sensitization by the extract of the bladder tissue of the same kind of rabbits.
1. With the auto-sensitized rabbits, the excretion of bacteria in the urine continued, but with the non-treated control group, the excretion disappeared within 8 days after infection.
2. At the initial stage of infection, the colonies were observed rather more in the urine with a higher dilution multiple, but such tendency was inhibited in the culture media added with EACA, AMCHA and T-AMCHA.
3. The fibrinolytic activity in the urine was found stronger in the bacteriuria at the initial stage of infection with Standard Fibrin Plate Method than in the urine of the control group.
With the lapse of time, however, the fibrinolytic activity became not to be different from that of the control group.
4. As regards the actions of EACA and T-AMCHA aginst the fibrinolytic activity in the urine, they both showed stronger inhibiting action to fibrinolysis of the urine with the higher concentration, and T-AMCHA was stronger in the inhibiting action than EACA at the same concentration.
5. Plasma fibrinogen increased in volume within 3 days after infection but the activation of fibrinolytic enzyme was not observed
6. The fibrinolytic activity of the kidney and bladder tissues themselves was marked within 10 days after infection.
7. With Ouchterlony Method, precipitine could not be proved.
8. Histologically, the more intensive change was observed in the rabbits which were previously given the sensitizing treatment.