男性インポテンスに関する研究

第VIII報 ^99mTc使用によるRadioisotope Penogram の研究

抄録

To help establish a reliable procedure for diagnostic discrimination between organic and functional impotence, attempts were made to find an acceptable formula for radioisotope penogram and to determine the best isotope for observation of changes in intrapenial blood flow.
¹³¹I-human serum albumin which we used as a qualified variety in the initial practice disclosed a flaw, because ¹³¹I required a relatively long period of 8 days to attain its half-life, eventually making mass dosing unavailable. Replacing this, ^113mIn-microcolloid was used with better results, since its half-life is as short as 1.7 hours. This ^113mIn, however, was reported still defective because of its indispensably strong acidity at pH 4.0, which caused vasalgia in rare instances at its intravenous injection. Then in continued pursuit of a satisfactory variety, we finally selected ^99mTc.
In preparing ^99mTc, a ^99mMo-^99mTc generator was used to eluate ^99mTcO^-₄ with sterile nonpyrogenic isotonic saline. This ^99mTcO^-₄ was intravenously injected in 11 impotence cases seen at the Department of Urology, Tohoku University Hospital, with one-time dose ranging 150-700μCi.
The results of our present experiments with ^99mTcO^-₄, though the number of cases is limited, may well support that this isotope, with its simple procedure safty and acceptably favorable penogram curves, is worth being used as a clinical routine.