To help establish a reliable procedure for diagnostic discrimination between organic and functional impotence, attempts were made to find an acceptable formula for radioisotope penogram and to determine the best isotope for observation of changes in intrapenial blood flow.
131I-human serum albumin which we used as a qualified variety in the initial practice disclosed a flaw, because
131I required a relatively long period of 8 days to attain its half-life, eventually making mass dosing unavailable. Replacing this,
113mIn-microcolloid was used with better results, since its half-life is as short as 1.7 hours. This
113mIn, however, was reported still defective because of its indispensably strong acidity at pH 4.0, which caused vasalgia in rare instances at its intravenous injection. Then in continued pursuit of a satisfactory variety, we finally selected
99mTc.
In preparing
99mTc, a
99mMo-
99mTc generator was used to eluate
99mTcO
-4 with sterile nonpyrogenic isotonic saline. This
99mTcO
-4 was intravenously injected in 11 impotence cases seen at the Department of Urology, Tohoku University Hospital, with one-time dose ranging 150-700μCi.
The results of our present experiments with
99mTcO
-4, though the number of cases is limited, may well support that this isotope, with its simple procedure safty and acceptably favorable penogram curves, is worth being used as a clinical routine.
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