1987 Volume 78 Issue 8 Pages 1306-1310
The inhibitory effect of sodium copper chlorophyllin (SCC) on the formation, growth and aggregation of calcium oxalate crystals were estimated by the use of Coulter counter TAII in the dilute and whole urine system.
In the dilute urine system, inhibitory activity of aggregation and growth was calculated from the change of the number and volume of crystals by seed crystal method. 1% volume of urine inhibited the aggregation and growth of added crystals at the final concentration of 0.01-1.0μg/ml.
In the whole urine system after determining the metastable limit, the formation and growth of crystals precipitated in response to a load of sodium oxalate (30μM) were quantified. SCC had a strong inhibitory effect on the formation and growth at the concentration of 10-100μg/ml. 1% volume of urine after the load of SCC markedly increased the inhibitory activity of aggregation and growth of calcium oxalate.
SCC therefore might have the possibility of treating the recurrent stone formers.
