1987 Volume 78 Issue 8 Pages 1311-1318
One hundred and thirty three cystectomy specimens obtained between 1978 and 1984 during treatment of cancer of the urinary bladder were analyzed by mapping. From gross and microscopic examinations, the growth pattern, grade, stage, mode of spread and intramural vessel invasion were found to be closely related with each other.
Most cystectomy specimens had evidence of diffuse epithelial abnormalities ranging from dysplasia to carcinoma in situ in areas adjacent to and/or distant from visible tumors. Carcinoma in situ associated with overt carcinoma was seen in 35 of 49 (71%) papillary tumors and in 30 of 48 (63%) nonpapillary tumors. Carcinoma in situ was more frequently seen in bladders containing high grade tumors than those containing low grade tumors. Dysplasia was frequently seen in bladders containing papillary tumors and was usually associated with carcinoma in situ; this suggests that dysplasia may develop to carcinoma in situ, also raises the suspicion that dysplasia may develop to papillary tumor without developing to carcinoma in situ.
