1987 Volume 78 Issue 8 Pages 1319-1322
The histochemical detection of prostate specific antigen (PA) was performed in three cases with primary or metastatic tumors to determine whether the origin of the tumor was prostate or not.
case 1: There was adenocarcinoma in biopsy tissues from both prostate and bladder. Both tissues were PA-positive, indicating that the origin of the tumor was the prostate.
case 2: There was adenocarcinoma in both prostate and bladder as in case 1. Both tissues were PA-negative, indicating that the origin was probably the bladder. Total cystectomy was performed and the pathological finding, mainly transitional cell carcinoma, supported the previous diagnosis.
case 3: There was metastatic adenocarcinoma in biopsy tissue from inguinal lymphnodes. The tissue was PA-positive, indicating that the origin was prostate.
The above mentioned, the histochemical detection of PA is a valuable adjunct to conventional histopathology in cases with a tumor extending in both prostate and bladder or a metastatic tumor.
