EXPRESSION OF Lex ANTIGENS IN RENAL ADENOCARCINOMA DIFFERENTIATION AND THE PROGNOSIS
1988 Volume 79 Issue 6 Pages 1090-1095
Details
1988 Volume 79 Issue 6 Pages 1090-1095
Immunohistochemical observation of human renal cell carcinoma tissue using monoclonal antibodies FH4 and FH6, directed to dif ucosyl Lex and sialosyl dif ucosyl Lex structure, respectively, was performed. According to the staining pattern, tisse samples of 50 cases of renal cell carcinoma were devided into the following three groups; Group A (FH4 positive, FH6 positive), Group B (FH4 positive, FH6 negative), and Group C (FH4 negative, FH6 negative). This immunohistochemical grouping correlates to histological grading, but not to clinical staging. Although histological grading did not correlate to prognosis of the patient's postoperative course, Breslow's examination revealed that the cases included in group A showd a significantly favourable postoperative course compared to the cases of the other groups (p<0.001).
These results indicate that expression pattern of these oncofetal antigens is a good parameter indicating the degree of tumor cell differentiation and malignancy, and reflects the prognosis of the patients.
