1988 Volume 79 Issue 6 Pages 1103-1107
A case of renal cell carcinoma with multiple pulmonary metastases achieved a complete response after a sequential combination therapy with interferon-γ(IFN-γ) and OK-432.
A 54-year-old male (K. M. #60528) was found to have multiple pulmonary coin lesions on chest X-ray films 6 months after radical nephrectomy for renal cell carcinoma of the right kidney. Aspiration needle biopsy confirmed the diagnosis of pulmonary metastases. Daily administration of IFN-γ at a dose of 9 million units was continued for 6 weeks, resulting in a progression of the disease, OK-432 was chosen as an adjuvant immunotherapy. After 12 weeks, the subjective symptoms improved and the pulmonary coin lesions became contracted, and the evaluation was a partial response. After 13 months with OK-432, the coin lesions disappeared completely, and the final evaluation was a complete response.
There is no report that single administration of OK-432 resulted in a complete response of renal cell carcinoma. Our speculation on the mechanism is that the sequential treatment with IFN-γ and OK-432 enhanced an immune response in host tumor relation as biological response modifiers.
