Detection of Collagen-cross Reactive Antigenic Components in Toxoplasma gondii

抄録

Using several immunologic techniques, the reactivity of anti-bovine collagen Type specific antibodies against Toxoplasma gondii was examined. Antibodies specific for bovine Type I, II and IV collagen showed relatively high affinity to the parasites. Treatment of T. gondii cysts with collagenase, induced cyst wall rupture. Results of the study suggest the presence of collagen cross-reactive component(s) in the parasite. Similarly, the cyst wall outer surface may contain amino acid sequences recognized by collagenase. This paper documents the first report of collagen cross- reactive antigenic components of T. gondii.