日本薬理学会年会要旨集
Online ISSN : 2435-4953
第97回日本薬理学会年会
セッションID: 97_2-B-O06-1
会議情報

一般演題(口頭)
自由行動マウスにおける光遺伝学による心臓ペーシング法を用いた身体反応が情動へ与える影響の解析
*山下 哲上之薗 知邑神戸 悠輝今井 哲司谷本 昭英桑木 共之
著者情報
キーワード: heart, pacemaker, heart rate, その他
会議録・要旨集 オープンアクセス

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抄録

Emotion affects physical reaction by the autonomic nervous system in the top-down process. However, there are few reported whether physical reactions, such as increased heart rate, might induce emotional changes like anxiety or fear responses. Here, we have investigated emotional behavior by controlling heart rate directly by a drug administration or an optogenetic-based cardiac pacing system in freely moving mice. First, the heart rate was controlled by ivabradine, an inhibitor of the hyperpolarization-activated cyclic nucleotide-gated channels. We found that ivabradine evoked bradycardia and partially reduced anxiety-like behavior. Second, heart rate was controlled by the optical cardiac pacing in freely moving mice. In many previous studies, the pacing was applied ex vivo or in anesthetized animals. Therefore, we developed the optical cardiac pacing system in awake, freely moving mice and simultaneously measured electrocardiograms. We found that Optically increased heart rate by using this system potentially enhanced anxiety-like behavior. These results suggested that emotional states are partially driven by heart rate in the bottom-up process. In conclusion, the brain function and the feedback from the physical reactions must be considered together to understand the mechanisms of expressed emotion.

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