脳梁膨大後部皮質のlate spiking細胞の膜電位は新皮質徐波と同期しない

抄録

Memory consolidation depends on the interaction between the hippocampus and the neocortex during slow-wave sleep, and the retrosplenial cortex (RSC) is thought to mediate this interaction. The coupling of hippocampal activity with neocortical slow waves plays a crucial role in memory consolidation, but the dynamics of slow waves in the RSC remain unclear. To investigate whether individual neurons of the RSC exhibit synchronized activity with slow waves, we conducted in vivo whole-cell patch clamp recordings to monitor the membrane potentials of RSC neurons simultaneously with local field potential recordings of slow waves from urethane-anesthetized mice. Among the 40 neurons recorded, 21 exhibited membrane potential dynamics synchronized with slow waves, while 19 exhibited brief and frequent depolarizations without phase locking to neocortical slow waves. Analysis of intrinsic membrane properties revealed that the former were regular spiking neurons, whereas the latter were late spiking neurons. These results suggest that regular spiking neurons, but not late spiking neurons, primarily receive inputs from the neocortex, implying parallel processing by these two cell types in the RSC.