主催: The Japanese Pharmacological Society, The Japanese Society of Clinical Pharmacology
会議名: WCP2018 (18th World Congress of Basic and Clinical Pharmacology)
開催地: Kyoto
開催日: 2018/07/01 - 2018/07/06
Since the publication of the first atomic structure of the Ca2+-pump (SERCA1a) in 2000 (1), more than 10 reaction intermediates that roughly cover the entire reaction cycle have been crystallised, allowing us to describe a fairly detailed scenario of ion pumping. We now know how SERCA1a binds two Ca2+ sequentially, utilising more abundant Mg2+ and K+ for acceleration. Furthermore, by developing a technology for visualising lipid bilayers in the crystals, we now begin to understand how P-type ATPases interact with phospholipids as an integral component of the pumping mechanism (2). In this lecture, I would like to overview our current understanding of the SERCA pumps through their atomic structures.
1. Toyoshima, et al. Nature 405, 647-655 (2000).
2. Norimatsu et al. Nature 545, 193-198 (2017).
