抄録
During the pregnancy process, by itself, a high level of stress and anxiety is generated to the future mother with negative effects for her and her baby. If the level of stress becomes excessive, this will generate prenatal stress that will produce an intrauterine environment unfavorable for fetal development that can negatively impact offspring increasing the risk of developing physiological dysfunctions. Furthermore, adverse conditions in the early postnatal period of life can induce alterations in oxidative and behavioral stress. Therefore, in the present work it is proposed to evaluate in plasma and brain the impact of perinatal stress disorders in animal models during fetal/neonatal development.
The anxious and depressive behaviors were evaluated by means of plus maze and forced swimming models, respectively. In the first case, it was observed that there is a significant increase in ethological measurements such as the number of rearings in the group of perinatal stress and grooming in the prenatal stress group in the adult stage, which has been associated with hyperactivity and anxious behavior. For the second case, there was a significant decrease in the number of escalation episodes in the perinatal stress and prenatal stress groups. While, there was a significant increase in immobility in the perinatal stress group, during the adult stage, related to a depressive behavior.
The initial results show that some markers of oxidative stress in plasma are significantly increased in animals subjected to perinatal stress. In particular, the total proteins and the activity of the enzyme arginase. While, there was a significant decrease in total sulfhydryls only in the prenatal stress group.
