MODULATORY EFFECT OF PENTAZOCINE AND PETHIDINE ON ANTICONVULSANT ACTIVITY OF PHENOBARBITONE IN 4-AMINOPYRIDINE-INDUCED SEIZURES IN MICE

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Management of epilepsy involved the use of many drugs, which sometimes include analgesics. Opioid analgesics being the second most commonly used drugs in insured epileptic patients are associated with neuro-excitation, ranging from nystagmus, extremity flexion, rigidity, myoclonus and seizures. The aim of this study was to investigate modulatory effect of opioid (Pentazocine and Pethidine) analgesics on 4-Aminopyridine (4-AP) induce seizure in mice. The anticonvulsant activity of Phenobarbitone (20 & 30 mg/kg), pentazocine (5 & 10 mg/kg) and pethidine (20 & 30 mg/kg) was evaluated using 4-AP-induced seizures in mice as well as co-administration between phenobarbitone and pentazocine or pethidine each. Phenobarbitone at doses of 20 & 30 mg/kg offered 80 and 100% seizure protection respectively. Pentazocine 10 mg/kg showed slight anticonvulsant effect with 20% protection but 5 mg/kg didn't. While Pethidine (30 mg/kg) provided 20% protection with no protection at 20 mg/kg. Co-administration of phenobarbitone (20 mg/kg) and pentazocine (10 mg/kg) abolished the effect observed with phenobarbitone alone. When phenobarbitone 20 mg/kg was interacted with pethidine (20) produced 0% protection by reversing the earlier protection obtained by phenobarbitone alone. In conclusion, pentazocine and pethidine have been shown to antagonize anti-seizure activity of phenobarbitone when co-administered in 4-AP-induced seizures in mice.