主催: The Japanese Pharmacological Society, The Japanese Society of Clinical Pharmacology
会議名: WCP2018 (18th World Congress of Basic and Clinical Pharmacology)
開催地: Kyoto
開催日: 2018/07/01 - 2018/07/06
Background: In publications of recent years, the synthesis of a numebr of complexes of germanium with a bioligang - tartaric acid (tartrate germanate). The introduction of the second metal into the tartrate germanium is a new stage in the creation of new biologically active substances (BAS). In addition to germanium, as the second metal an essential element zinc was offered.l
Purpose: To study an acute toxicity of new biologically active substance - tartratogermanate zinc.
Materials and methods: An acute toxicity in mice and rats under the conditions of oral (or.), subcutaneous (s.c.) and intraperitoneal (i.p.) administration has been studied. The toxicity criteria of the tested compound were as follow: LD50, absolute toxicity, the acute toxic effect zone, the summary toxicity index etc. These indexes were calculated with the help of "StatPlus 2009" program (AnalystSoft, USA, 2009).
The results: According to the obtained results the LD50 index of zinc-tartratogermanate in mice was 87.20 mg/kg (i.p.), 167.05 mg/kg (s.c.), and 1675 mg/kg (or.); in rats - 141.57 mg/kg, 236.52 mg /kg, and 2792.45 mg/kg correspondently. The new compound of zinc tartratogermanate belongs to low-toxicity compounds (IV class of toxicity) in the conditions of intraperitoneal, subcutaneous, and oral administration in two studied animal species. Zinc-containing compound of tartratogermanate showed lower toxicity than similar compounds with copper that had been studied before. For example, the LD50 index of copper-tartratogermanate after i.p. administration was 36.88 mg/kg (in mice) and 78.15 mg/kg (in rats); after oral administration - 385.57mg/kg (in mice) and 794.26 mg/kg (in rats) correspondently. According to the obtained results, the variability of the lethal doses for various routes of administration of zinc tartratogermanate was 1.35-1.50 (in mice) and 1.24-1.37 (in rats). Intgral safety of the new BAS shows that compound with zinc was safer that analogue compound with copper both after oral intake and intraperitoneal injection.
Conclusions: Relatively low toxicity of new compound zinc tartratogermanate indicated the prospective for its further preclinical studied as potential medicine agent.
