一般論文
湿式造粒法における打錠用顆粒の結合剤分布の均一性及び顆粒硬度の圧縮成形性への影響
キーワード:
compressibility,
uniformity of binder distribution,
granule hardness,
mothod of binder addition,
wet granulation
2000 年 60 巻 1 号 p. 71-76
詳細
2000 年 60 巻 1 号 p. 71-76
The effects of uniformity of binder distribution of granules and granule hardness on the compressibility of granules manufactured with different methods of binder addition (solution addition method and powder addition method) on various wet granulation methods were investigated. As a result, the uniformity of binder distribution of granules was found to be the main factor in controlling the compressibility of granules for tablets on wet granulation compared with granule hardness. It was suggested that uniform binder distribution of granules on wet granulation is important for the excellent compressibility of granules for tablets.
