ノート
EDTANaを含有したポリビニルアルコールゲル坐剤からのインスリンの直腸吸収
2003 年 63 巻 2 号 p. 105-110
詳細
2003 年 63 巻 2 号 p. 105-110
The rectal absorption and hypoglycemic effects of insulin after the administration of poly(vinylalcohol) (PVA) gel suppositories containing insulin and 1% sodium EDTA were investigated in rats. PVA gel suppositories were prepared using the freeze-thaw cycle method. Insulin was administered at a dosage of 12.5 or 25 U/kg. The mutarotase-GOD method was used for measuring plasma glucose levels. An automatic EIA system was employed for measuring plasma insulin levels. After the administration of insulin at 25 U/kg, significant and continuous hypoglycemic effects as well as high plasma insulin concentrations were observed. It is believed that insulin was released from the PVA gel suppository at a constant rate. Our results indicate that PVA gel suppositories are able to maintain low levels of plasma glucose for long periods of time.
