Journal of Radiation Research
Online ISSN : 1349-9157
Print ISSN : 0449-3060
X-ray Effects on the Glycolytic Regulatory Enzymes in Rat Thymocytes and their Modification by Cysteamine
山田 武
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ジャーナル フリー

1969 年 10 巻 3-4 号 p. 113-120

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Cysteamine afforded marked protection against the effects of X-irradiation on both dose-dependent accumulation of fructose-1, 6-diphosphate and ATP depletion to an approximately equivalent extent, giving the dose-reduction factor of about 2. This was considered as support for the view that both phenomena are closely related and arose from a common event. Little protection was afforded under the same conditions against irradiation-induced accumulation of pyruvate and lactate in the lower dose range. Possible mechanisms underlying these phenomena are discussed.
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