Early skin reactions were observed on mouse legs irradiated in the spread out Bragg peak (SOBP) of a 250MeV proton beam, and the unmodified Bragg peak of that beam, or 290kVp X-rays. The fifty percent moist desquamation doses for the proton SOBP, proton peak, and for X-rays were 29.7Gy, 24.5 Gy, and 21.9Gy, respectively. The Bragg peak caused more severe early skin reactions than did SOBP.
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