抄録
We investigated mutations induced by gamma-rays in major organogenesis using New HITEC mice, which have rpsL gene as a reporter for mutation detection. The pregnant mice were exposed to 2 Gy of gamma-rays on day 9.5 of gestation. On day 18.5 of gestation, fetuses were removed by cesarean operation, and forelimb, hindlimb and tail were extracted and the mutation frequencies were analyzed. The mutation frequencies in forelimb, hindlimb and tail of the irradiated group increased about 2 times compared with the control group. In contrast, after irradiation, most fetuses had tail anomaly, but there were very few fetuses had malformations of forelimb and hindlimb. The relationship between radiation-induced malformation and mutation was not recognized. [J Radiat Res 44:419 (2003)]
