抄録
The remarkable progress of research in genome science and regenerative medicine will bring new treatments for radiation casualties. This program try to reach to the goal of the establishment of the world center of excellence (COE) in 21st century for Radiation Casualty Medical Research. We also aim to nurture the next generation of young researchers and physicians in this field. Radiation exposure can cause genome damage and induce acute disorders such as multi-organ failure and late disorders such as cancers. In our research program, we are attempting to develop a diagnosis and prevention method for damaged genomes, new treatments for radiation-induced cancers, and methods of tissue-regeneration using pluripotent stem cells. Studies of molecular mechanisms of repair and cellular response to radiation-induced genome damage are also our major research projects. We are analyzing genes associated with leukemia and other cancers and establishing a monitoring system based on the information from genome alterations. From this, we can develop a new system of prevention and treatment of radiation exposed patients. Our ultimate goal is the achievement of a comprehensive medical system that is capable of dealing with all types of radiation injury based on the radiation dose estimated from the information of damaged genome and physical dosimetry.
