Abstract
Some researchers reported effects of lifespan prolongation were due to improve antioxidant functions. We reported antioxidant capacities in various tissues of mice were enhanced by low dose-rate irradiation. We also found Type II diabetes model mouse consecutively for low dose-rate gamma ray (0.70 mGy/hr) irradiation changed biological effects, such as decreased urine glucose level, and lifespan prolongation. These phenomena might be insulin function contributed. In human premature-aging syndrome model mouse (klotho), there are some reports asthenia of insulin sensitivity contributes to lifespan prolongation. We used female klotho mouse as elucidation of the action that low dose-rate irradiation gave to lifespan prolongation, and measured plasma insulin concentration and SOD activity. I measured of lifespan of the mice starting at 28 days old till the death with at a dose-rate of 0.70 mGy/hr consecutively. Measurements of the pancreatic SOD activity and the insulin concentration were used for 1-6 weeks irradiated from 28 days old klotho mouse.
The lifespan of the irradiated group was prolonged. In addition, we first shown, one of the mice in the irradiation group went over 100 days. In the irradiated group SOD activity slightly decreased after the irradiation. The plasma insulin concentration less decreased in the irradiated group.
These results indicated that the low dose-rate irradiation prolonged lifespan of this mouse, and that the antioxidative capacity in the pancreas to protect beta cells from oxidative damage, and then to kept the insulin secretion function.
