Abstract
In the present study, we examined radioprotecition of tocopherol monoglucoside (TMG), a water-soluble vitamin-E derivative. The radioprotection by TMG was evaluated as 30-day survival of C3H/HeSlc 10-week-old male mice after X-ray irradiation. TMG (650 mg/Kg BW) was administered subcutaneously to mice immediately after 7.0 Gy (0.5 Gy/min) whole body X-irradiation. The survival of TMG-injected mice after irradiation was 80.0 %, while that of control mice was only 26.7 %. We also evaluated the prevention by TMG of radiation-induced tumors of rat mammary. When dams at day 21 of lactation were exposed to X-rays at a total dose of 1.5 Gy (0.3 Gy/min) and then treated with diethylstilbestrol as a tumor promoter, the incidence of mammary tumors (81.8 %) was increased compared to that of the non-irradiated control (0 %). The administration of TMG (600 mg/ Kg BW i.p.) after the irradiation significantly reduced the incidence (59.0 %). TMG is an effective agent for protection of bone marrow death of mice even when administered subcutaneously, and for prevention of radiation-induced mammary tumors of rats.
