The Japan Radiation Research Society Annual Meeting Abstracts
The 51st Annual Meeting of The Japan Radiation Research Society
Session ID : FP-11
Conference information

Radiation Epidemiology
Neuronal cell adhesion molecule L1 expression and learning ability in the rat model received X-irradiation
*Xue-Zhi SUNRui ZHANGChun CUIKazuhiko SAWADASetsuji HISANOYoshihiro FUKUIHidenori YONEHARA
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Keywords: irradiation, L1, learning
CONFERENCE PROCEEDINGS FREE ACCESS

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Abstract
This study was designed to present evidence to clarify the relationships between learning ability, neuronal cell adhesion molecule L1 expression and hippocampal structural changes in the rat model received X-irradiation at an embryonic stage. Water maze task indicated that all of the irradiated rats failed to learn the task in the whole training procedure. Their latency to the platform and swimming distance were significant differences from those sham-treated controls. Histological studies showed that the hippocampal ectopias induced by X-rays in the CA1 were involved in the spatial learning impairment, in which they hampered normal processes in learning development and transmission of information. On the other hand, L1 expression in the hippocampus was examined with Western blot analysis. The results indicated a lower content of L1 in the irradiated rats. A decrease in L1 might be one of reasons to cause disorganization of the septohippocampal pathways. These findings suggest some mechanisms of spatial learning impairment can be attributed to the formation of the hippocampal ectopias and redaction of L1 following prenatal exposure to X-irradiation.
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© 2008 The Japan Radiation Research Society
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