Abstract
Irreversible electroporation (IRE) had been studied as an effective treatment for pancreatic cancer. However, if the cancer recurs, reoperation may be required. We propose an implantable IRE system to reduce the invasiveness of reoperation. The proposed system transmits power wirelessly to the implanted circuit and steps up the voltage to 3 kV. High voltage generates a large electric field during wireless power transmission, which causes stimulation and heating effects in the biological tissues around the coil. Therefore, it is necessary to design a system that applies a high voltage at the treatment site and transmits power at a low voltage in the transcutaneous transformer. In this study, the stimulation and thermal effects in biological tissues were simulated when the outer diameter of the receiving coil of the transcutaneous transformer was varied. Furthermore, the voltage was measured and simulated at each point of the system. As a result, for Type B (outer diameter: 50 mm), the maximum effective value of Ein was 105.0 V/m, and the maximum local SAR was 1.88 W/kg. Both the stimulation and thermal effects were below the limit values.
