Abstract
To be utilized for plasmafiltration, we evaluated several microporous membrane with using testcells (active filtration area=20-400cm2) and heparinized fresh bovine blood, in perfusion system. Then, we inputed the test-cell data to microcomputer so as to obtain large cells. Through this procedure, Disk-Pile-type plasmpheresis cells (active filtration area=3000-6000cm2) was designed. We evaluated the cells in 3hrsperfusion at 100ml/min blood flow rate on adult mongrel dogs. As a result, plasma was obtained approximately 40ml/min of filtration flux without excessive hemolysis, and with favourable protein permeabilily. We intend to perform clinical evaluation from now on after several additional investigation.
