イオン交換樹脂ならびに吸着型樹脂を用いた尿毒症成分の吸着除去

抄録

Urea was removed effectively from serum by the treatment with strongly acidic cation exchange resin (H). But the concomitant change in pH of the treated serum was one of the problems involved in the application of ion exchange to clinical use.
In order to settle this problem we have investigated the composition of the mixed bed which is capable of keeping pH constant as well as removing several uremic toxins including urea. The horse serum to which were added urea, uric acid, creatinine, meth ylguanidine and vitamine B₁₂ was treated with various mixed beds, and changes in pH and in contents of these five additives were determined. As a result of testing several kinds of mixed beds of cation exchange resin (H) and cation exchange resin (Na) or cation exchange resin (H) and anion exchange resin (OH), the mixed bed of cation exchange resins 2000 (H) and 200C (Na) (1:9) was found to be the most suitable for both preventing change in pH and removing the five additives.
Although ion exchange was effective in removing the low-molecular and high-polar substances, it was not suitable for removing the middle-molecular and low-polar substance. Then synthetic adsorbents, XAD2, 4, 7 or 8, with low (2, 4) or intermediate (7, 8) polarity were studied for their capacity for removing the low-polar substance. XAD7 was found to be suitable for removing vitamine B₁₂ from the horse serum.
The mixed bed of 2000 (H), 2000 (Na) and XAD7 (1:7:8), which was supposed to possess the broad adsorption spectrum, was found to be suitable for simultaneously romoving uremic toxins with various polarity.
Hereafter the mixed bed of ion exchange resins and charcoal or other adsorbents instead of XAD7 will be studied.