REMOVAL OF BILIRUBIN BY DIRECT HEMOPERFUS ION WITH AN IMPROVED CHARCOAL DERIVED FROM THERMOSETTING RESIN (CTSR-3)

Abstract

We have previously reported a new type of charcoal derived from thermosetting resin (CTSR-1). Direct hemoperfusion (DHP) with this charcoal resulted a better bilirubin adsorption but it brought a marked decrease in blood cell counts.
Here, we present an improved charcoal with poly-HEMA (CTSR-3). CTSR-3 was shown to be better than CTSR-1 in both bilirubin adsorption and cell counts. The release of microparticles from CTS R-3 into the blood circulation was less than that from other activated charcoal.