高分子材料表面への血小板粘着とアノレブミン吸着に及ぼす流れの影響

抄録

The effects of shear rate on the rate of platelet adhesion and albumin adsorption onto polymer surfaces under controlled plate-flow conditions were studied in vitro. The experiments were carried out using human platelet-rich plasma and fluoresceine-isothiocyanate labeled bovine serum albumin.
Albumin adsorption rates onto polyethylenetelephthalate (PET) films was not affected by the shear rate for a range of shear rate from 0 to 141 sec^-1 On the other hand, platelet adhesion onto PET films (from 0 to 99 sec^-1) and fluorinated ethylene-propylene copolymer (FEP) films (from 0 to 33 sec^-1) was greatly affected by the shear rate. The shear rate also affected the morphologicol feature of the platelets adhered on PET films.