Hemodiafiltration repeating a period without filtering protein and one filtering considerable albumin, transferrin, etc. per treatment, switched for 2-3 mos have been performed in 3 patients with numerous complications. Changes in clinical conditions have been observed and the ultrafiltrate obtained from the hemofilters was analyzed. The Rhône-Peulenc RP-6 and the Toray BlL was used for the non-albumin filtering hemofilter and the Cordis Dow Duo-flux, for the albumin filtering hemofilter.
Several effects were seen at Duo-flux treatment period. Elevation of hematocrit was striking, ectopic calcification unable to be treated at RP-6 and BlL treatment period disappeared in 2 patients and pruritus and irritation was eliminated in the 2 patients.
Although 5-8g of protein was lost at Duo-flux treatment period, there was no reduction in serum total protein and transferrin. Nine kinds of protein with molecular weight smaller than transferrin (8, 000 dalton) were detected in the ultrafiltrate obtained at Duo-flux treatment period. Although a striking increase of removal was seen at fraction a which is of the highest molecular weight out of middle molecular fractions, there was no difference in the removal of middle molecular fractions smaller than this.
