抄録
This study compares the effect of pulsatile and non-pulsatile flow upon the plasma catecholamine concentration. Nine dogs weighning between 16 and 25Kg were anesthetized with pentobarbital and mechanically ventilated with pure oxygen. Bypass system was constructed according to modified Litwak's technique. Aortic root was cross clamped during bypass, so that left ventricle supplies only to coronary system (so called hybrid type of left heart bypass). After non-pulsatile left heart bypass of 40 min, adrenaline and noradrenaline increased significantly up to 2 or 3 times of control lebel. After pulsatile left heart bypass, Increase in plasma catecholamine concentration was much less than in non-pulsatile bypass. It is conculuded from this study, that pulsatile flow perfusion is superior to non-pulsatile perfusion to maintain physiological circulation.
